That sh-t should be banned. No diarrhea or vomiting or seizures. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. She had some good days and we were hopeful but ultimately, she steadily declined. Each medication combats different pests. This happened to our 2yr old frenchie last Friday. How long did the itching last with your pet. He seems dehydrated. Read the package insert and it does list tremors and seizures as a side effect. After doing more research on their monthly medication, I will no longer use Simparica Trio nor ever recommend it. If it was due to the Simparica, then it would expected to be resolved within a day or two. Thank all who have posted to bring this subject to light. First month, the one threw up, same thing second month. My vet reached out to Simparica Vet Rep, who, I was told, stated they were unaware of this neurological side-effect? This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. Can blocking GABA receptors also cause inflammation of spine? Another difference is flavor. However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. A few months back he started with a morning vomiting always on his empty tummy. She's been given this dosage for over a year. Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. You don't think I'm going to continue with this poison. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. Simparica has possibly shown no severe side effects that may concern the health of dogs. She is still in the vet since 3am. 98. For all symptoms to be reversed & to return to normal . I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. I went to zoetis and Expressed my views and they said the FDA report meant nothing and it was in America. I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. My vet seems skeptical that this is related to simparica but it seems clear to me, although I realize that anecdotal cases don't prove it. Our vet pushed this new drug for this tick season claiming the drug we used previously they had 11 dogs in the previous year were diagnosed with Lyme disease and they no longer had confidence in that drug. When did you stop giving the Simparico Trio? Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. She has been the healthiest, happiest dog. I cant believe how long this thread is. Thanks! How is ur puppy? You can do this by reporting to the drugs manufacturers, who are required to report this information to the FDA, or by submitting a report directly to the FDA. Very dissapointed with my vet for not informing me of the risk this has on my dog. Very "out of it". I put him on boiled chicken & rice and got him calmed down. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. If anyone has suggestions or knows how else I can help my little guy please let me know. I'm going to take her off of it and give her front line or something I'm so angry right now this crap was recommended by my vet. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. I feel the manufacturer should pay my test bills and meds .. my doc talked me into this regimine of meds and my previous dog did well on sorresto color and heart word med .. any clue on who I contact ? The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. Some years back my husband gave vet approved & sold oral flea/tic medication to each of our 2 Standard Poodles. I took him back to the vet and explained my concern that it was from the Simparica Trio and they didn't seem concerned that it was the issue. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. First dose was on 4/1 and 9 days later he was vomiting goop (yellow thick goo), he would drink water and vomit. He was a normal dog before the medicine Simpatico Trio . I don't give him much treat eather. At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. Needless to say, we will no longer be giving this to our lab or our other dog. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. Please advise! Certain age, breed predispositions. Our dog was killed by this poison within 15 hours after taking one dose. She has been on it for 6 months. She seems so much happier in herself but until she comes off the keppra completely I wont know if it's a reversible problem. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. I will have to keep an eye out on her. My lab puppies have been taking Simparica Trio for 2 months. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. This was the first time she was given this drug and will be the last. This is still going on weeks later. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. A day and a half after her 3rd dose of Simparica she had a really bad gran mal seizure and we though she was going to die. Our Pickles died last year after just 3 doses, and our vet basically said we were crazy. Vet says Simparica is not the reason for his condition, but he was totally fine prior to taking Simparica!! My 9 month old puppy started acting very lethargic after taking simparica trio. He had it once before with no issues. Im going to another vet and discontinuing simparica. We were so upset - I vowed to never use oral flea treatment again. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. We wont be using this medicine ever again! Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? Vet did all kinds of tests but said it couldnt be simparica. Got a new GS when the old one died. Our vet recommended putting him on phenobarbital. My Lab mix has had 2 doses of this med. I gave him this medication last Thursday. Once again peed in my office on Saturday. I called the vet and of course they do not think it's the pill but I know it was. As per chewable tablets, this medicine is safe for all breeds of dogs. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. its only been about 4 days since and its been a steady decline. Same as you describe. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching . We ended up encouraging him to eat something by spoon feeding him. Last year I gave them this but didn't notice any issues. No more of this poison for him. Sarolaner is an acaricide (kills ticks and mites) and insecticide (kills fleas) belonging to the isoxazoline class of drugs. I'm so upset. I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. Only some dogs show this symptom. They can also have major side effects. I will not be continuing with this treatment. like what??? The company's thinking must be the profits outweigh the loses from any lawsuits lost its important to note that the law treats animals as property and the fix value of a dog is quite small and limited. This month 5/1 gave him another dose and here we are 12 days later with diarrhea and no appetite. 3 months ago he began having seizures, he had one every day for a week. Trifexis is much safer and I really don't care about the ticks - I can pull those off. He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. These dog training tips will help you get started. It's unique because it kills more types of parasites than any other combination product available to date. He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. I just found these comments and I am feeling terrible. Today June 1,2022 she is still having neurological problems. He seems sometimes anxious and is sensitive to noise outside. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. The initial trial had seizure results but supposedly only in dogs with seizure history. My dog has been on simpatico trio for 5 months .. and still got a deer tick .. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewablefor protection against: . What You Need to Know About the Lyme Vaccine for Dogs. He had no medical problems before this, and I took him to the vet every year he ended up dying two weeks later , I took him to the vet first they told me he wasnt gonna make it to leave him there and I told him no if he isnt gonna make it, hes going to pass away in my arms at home with me and his family why took him to a different vet not the same one I confronted the woman that gave me that medicine. After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. Ticks are horrible here in Maine. I'm so scared. Im convinced it was caused by this drug. This simple-to-give oral monthly treatment protects dogs against heartworm disease as well as against ticks and fleas and intestinal worms like roundworms and hookworms. Simparica Trio is not effective against adult heartworms. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. He developed these big sores which scab over quickly, hair falling out here and there. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. They said , he has a Autoimmune Hemolytic anemia . I sadly started my beautiful dog on Simparica Trio on May 1, 2021. Millions of dogs take flea and heartworm meds without side effects but that's not to say it doesn't happen or that an alternative would be safer. In other words, they can make it easier to have a seizure in susceptible dogs. Different vet. I had to give him flea prevention because he goes to Daycare. Yea so what about the 10 percent? I am so mad at myself and so upset that I am the one that has made him sick. She does have history of seizures. Read package insert - yes was tested on female dogs who were bred. Wore off or is this going to be a permanent issue possibly getting worse a year pill... 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